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A collection of nonclinical studies & assays; customization is possible.

Catheterization: Intracerebral ventricular (IVC)

Surgical Procedure

Intracerebral ventricular catheterization (ICV) utilizes a port implanted under the scalp to accommodate access into the cerebral ventricles. This intrathecal delivery method enables the administration of therapies directly into the central nervous system bypassing the blood-brain-barrier. The Ommaya reservoir is one example of an ICV port. It consists of a dome-shaped silicone rubber connected to a catheter and pump, which allows for convenient mixing of injected therapeutics.

Ultrasound and stereotactic guidance facilitate accuracy in catheter placement. Additional optimization includes using frameless electromagnetic image-guidance, reducing the risk of procedure-associated intracranial hemorrhaging.

Models

Mouse, NHP, Rat

Industry Market

Pharma

Phase

Nonclinical

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About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC. Learn more about our commitment to replacing, reusing and refining nonclinical research models.

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Labcorp is a leading global life sciences company that includes contract research and developmental services to the pharmaceutical, medical technology, crop protection and chemical industries.

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