Characterization of functional impact and disease biomarker responses under one roof

Experienced in vitro microbiology and in vivo teams

Bespoke validation to meet sponsor requirements and deadlines

Access comprehensive services for antimicrobial development, including a wide range of validated in vivo models complimented by full in vitro support. Have a custom need? We are happy to collaborate to develop and validate bespoke models tailored to your criteria. We also offer stand-alone in vitro assays to investigate efficacy against a wide range of bacterial and fungal pathogens. With expertise in efficacy models, pharmacokinetic (PK) models, and safety models, you can count on quality studies with accelerated data delivery. 

In vivo models of infection:

  • 肺部曲霉菌感染,小鼠
  • 白色念珠菌败血症,小鼠
  • 乙型肝炎病毒(HBV),小鼠
    • HBV感染人类肝脏嵌合小鼠模型(PXB®小鼠)
  • 流感(H1N1),小鼠/雪貂
  • 耐甲氧西林金黄色葡萄球菌(MRSA)中性白细胞缺乏性大腿感染PK/PD模型,大鼠
  • 铜绿假单胞菌肺部感染,小鼠
  • 呼吸道合胞体病毒(RSV)肺部感染,小鼠
  • 肺炎链球菌肺部感染,小鼠
  • Streptococcus pneumoniae sepsis model, mouse

In vivo study support services:

  • Preparation of bacterial/viral/fungal infective doses, including agar bead prep for bacterial and fungal respiratory models
  • Organ/tissue bioburden counts
    • Viral titre assays (CPE assay, Plaque assay)
    • Bacteriophage plaque assays

In vitro antimicrobial efficacy:

  • In vitro Minimum Inhibitory Concentration (MIC) assays
    • Aerobic/anaerobic bacteria and fungal pathogens (Hazard class 2)
    • Antibiotic resistance/susceptibility testing

Non-animal model for assessment of acute toxicity and antimicrobial efficacy:

  • Galleria mellonella wax moth larva model  - TruLarvTM